The Oxford Thesaurus An A-Z Dictionary of Synonyms - afflictionn.

1) hardship, misery, misfortune, distress, ordeal, trial, tribulation, adversity, suffering, woe, pain, grief, distress, torment, wretchedness: Moses saw the affliction of his people in Egypt. 2) curse, disease, calamity, catastrophe, disaster, plague, scourge, tribulation, trouble: He often observed that greed was the affliction of the middle class.